Abstract
We recently demonstrated the role of M1 muscarinic receptors (M1R) in modulating oxidative stress in liver and hepatocytes (Urrunaga et al., 2015) [1]. Here we provide data regarding the effect of a novel M1R agonist, VU0357017 (Lebois et al., 2010) [2], on H2O2-mediated hepatocyte injury, the effect of an M1R antagonist VU0255035 (Sheffler et al., 2009) [3] on catalase and super oxide dismutase (SOD) activities in H2O2–treated hepatocytes in vitro, and finally, the effect of M1R ablation on hepatic catalase activity in acetaminophen (APAP)-treated mice.
Highlights
We recently demonstrated the role of M1 muscarinic receptors (M1R) in modulating oxidative stress in liver and hepatocytes (Urrunaga et al, 2015) [1]
We provide data regarding the effect of a novel M1R agonist, VU0357017 (Lebois et al, 2010) [2], on H2O2-mediated hepatocyte injury, the effect of an M1R antagonist VU0255035 (Sheffler et al, 2009) [3] on catalase and super oxide dismutase (SOD) activities in H2O2–treated hepatocytes in vitro, and the effect of M1R ablation on hepatic catalase activity in acetaminophen (APAP)-treated mice
Analyzed No pretreatment Enzyme activity and cytotoxicity assay Medical College of Georgia, Augusta, GA The data are supplied with this article
Summary
Animal experiments were conducted in accordance with the Guide for the Care and Use of Laboratory Animals prepared by the United States National Academy of Sciences (National Institutes of Health), approved by the Institutional Animal Care and Use Committee, and described in detail previously [1]. The stored liver tissue from the Chrm À / À and WT mice were used to assess catalase activity
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