Abstract
Toxoplasma gondii pathogen is a threat to human health that results in economic burden. Unfortunately, there are very few high-efficiency and low-toxicity drugs for toxoplasmosis in the clinic. (+)-Usnic acid derived from lichen species has been reported to have anti-inflammatory, antibacterial, anti-parasitology, and even anti-cancer activities. In associated with the published article “Effects of (+)-Usnic Acid and (+)-Usnic Acid–Liposome on Toxoplasma gondii” [1], this dataset article provided the detailed information of experimental designing, methods, features as well as the raw data of (+)-usnic acid and (+)-usnic acid–liposome on toxoplasma in vivo and vitro. (+)-Usnic acid may be a potential agent for treating toxoplasmosis.
Highlights
Toxoplasma gondii pathogen is a threat to human health that results in economic burden
There are very few high-efficiency and low-toxicity drugs for toxoplasmosis in the clinic. ( þ)-Usnic acid derived from lichen species has been reported to have anti-inflammatory, antibacterial, anti-parasitology, and even anti-cancer activities
In associated with the published article “Effects of ( þ)-Usnic Acid and ( þ)-Usnic Acid– Liposome on Toxoplasma gondii” [1], this dataset article provided the detailed information of experimental designing, methods, features as well as the raw data of (þ )-usnic acid and ( þ)-usnic acid–liposome on toxoplasma in vivo and vitro. ( þ)-Usnic acid may be a potential agent for treating toxoplasmosis
Summary
Figures Microscope (Olympus, Japan), H-600 Transmission Electron Microscope (Hitachi, Japan) Raw, analyzed Infectiousness of toxoplasma in vitro and in vivo in the presence of usnic acid. The virulent RH strain of Toxoplasma gondii was cultured by intraperitoneal inoculation of mice and Rat cardiofibroblasts were prepared for primary cardiomyocyte monolayer cultures from 2 to 4-day-old Sprague–Dawley rats in our laboratory Xi’an Jiaotong University Health Science Center. This is the first report about development of (þ )-usnic acid against toxoplasma. The differential experimental models indicated the potential function of ( þ)usnic acid and its liposome to toxoplasma tachyzoites. Provided a new application guidelines for (þ)-usnic acid to treat toxoplasmosis. We exemplified the viability of Toxoplasma gondii treated by (þ)-usnic acid in cell with typan blue and Giemsa staining We exemplified the viability of Toxoplasma gondii treated by (þ)-usnic acid in cell with typan blue and Giemsa staining (Figs. 1–3)and the survival rate of infected mice (Fig. 4) and ultrastructural changes of toxoplasma in vivo (Fig. 5)
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