Data on thermal and hydrolytic stability of both domiphen bromide and para-bromodomiphen bromide

Laura Fumagalli,Alessandra Moretto,Ettore Gilardoni,Claudia Picozzi,Giulio Vistoli,Marina Carini

doi:10.1016/j.dib.2018.08.152

Abstract

In this data article, HPLC analyses were applied to investigate the hydrolytic and thermal stability of domiphen bromide a FDA approved OTC ingredients endowed with antimicrobial activity. The data obtained by stressing domiphen bromide in acid, base and thermal conditions enlarge the research article published by Fumagalli et al. [2]. The chromatograms herein presented reveal that domiphen bromide is stable under acidic and thermal stress while the treatment with base yield to a by-product. The para-bromo derivative, p-bromodomiphen bromide shows the same behavior under the up mentioned stressed conditions.

Highlights

Data ArticleData on thermal and hydrolytic stability of both domiphen bromide and para-bromodomiphen bromide
In this data article, HPLC analyses were applied to investigate the hydrolytic and thermal stability of domiphen bromide a FDA approved OTC ingredients endowed with antimicrobial activity
Chemistry Biopharmaceutical Analysis Figures Elite_La Chrom HPLC (VWR/HITACHI, Milan, Italy/Tokyo, Japan) apparatus equipped with a L-2130 high pressure quaternary gradient delivery system, a L-2455 diode array detector (DAD), a L-2300 column oven and a L2200 autosampler

Summary

Data Article

Data on thermal and hydrolytic stability of both domiphen bromide and para-bromodomiphen bromide. Article history: Received 30 June 2018 Accepted 24 August 2018 Available online 31 August 2018 abstract. In this data article, HPLC analyses were applied to investigate the hydrolytic and thermal stability of domiphen bromide a FDA approved OTC ingredients endowed with antimicrobial activity. The data obtained by stressing domiphen bromide in acid, base and thermal conditions enlarge the research article published by Fumagalli et al [2]. The chromatograms presented reveal that domiphen bromide is stable under acidic and thermal stress while the treatment with base yield to a by-product.

Specifications table

Value of the data