Data on the sub-chronic toxicity in rats after 30 days of oral realgar administration and the accumulation and distribution of arsenic species

Yan Yi,Shuangrong Gao,Jing Xia,Chunying Li,Yong Zhao,Yushi Zhang,Aihua Liang,Shen Ji

doi:10.1016/j.dib.2018.12.011

Abstract

These data are related to the research “The accumulation and distribution of arsenic species and association with arsenic toxicity in rats after 30 days of oral realgar administration” (Yi et al., 2019) [1]. These data include the rat body weights, haematology, electrolytes, coagulation and biochemical parameters, and relative organ weights after 30 days of oral administration of realgar, which was consistent with the current OECD guideline “Repeated Dose 28-Day oral Toxicity Study in Rodents”. The data also include the content of arsenite (As(III)), arsenate (As(V)), dimethylarsinic acid (DMA), monomethylarsonic acid (MMAV), arsenic betaine (AsB) and arsenic chrome (AsC) in rat blood, liver, kidneys, brain and urine after single-dose and 30-day oral administration of realgar.The provided data are intended to demonstrate whether realgar has short-term toxicity and the role of accumulated arsenic species in realgar toxicity.

Highlights

Data ArticleArticle history: Received 31 October 2018 Received in revised form 4 December 2018 Accepted 4 December 2018 Available online 07 December 2018 abstract
The provided data are intended to demonstrate whether realgar has short-term toxicity and the role of accumulated arsenic species in realgar toxicity. & 2019 The Authors
Measurements of arsenic metabolites and accumulation were performed on an Agilent 7700ce ICP-MS instrument coupled with the Agilent 1200 Series HPLC system

Summary

Data Article

Article history: Received 31 October 2018 Received in revised form 4 December 2018 Accepted 4 December 2018 Available online 07 December 2018 abstract These data are related to the research “The accumulation and distribution of arsenic species and association with arsenic toxicity in rats after 30 days of oral realgar administration” (Yi et al, 2019) [1]. These data include the rat body weights, haematology, electrolytes, coagulation and biochemical parameters, and relative organ weights after 30 days of oral administration of realgar, which was consistent with the current OECD guideline “Repeated Dose 28-Day oral Toxicity Study in Rodents”.

Data source location Data accessibility Related research article

Value of the data

Time AsC

Arsenic species