Abstract
Ethyl cellulose (EC) based microparticles (MPs) could provide sustained release for Huperzine A. The drug release mechanism of MPs was exploited to achieve an ideal drug release profile. We previously found that the wettability of MPs greatly contributed to facilitating drug release, which was detailed in a research article entitled “Huperzine A loaded multiparticulate disintegrating tablet: Drug release mechanism of ethyl cellulose microparticles and pharmacokinetic study” (Peng et al., 2019) [1]. In this article, the influence of different polymers and drugs on the drug release behavior was investigated to broaden or compensate this finding. Besides, powder characterization of MPs was used to evaluate the further application of MPs for tablets.
Highlights
Data on the drug release profiles and powder characteristics of the ethyl cellulose based microparticles prepared by the ultra-fine particle processing system
We previously found that the wettability of MPs greatly contributed to facilitating drug release, which was detailed in a research article entitled “Huperzine A loaded multiparticulate disintegrating tablet: Drug release mechanism of ethyl cellulose microparticles and pharmacokinetic study” (Peng et al, 2019) [1]
Pharmaceutics Controlled drug delivery system Tables, figures ZRS-8G dissolution tester (TDTF, Tianjin, China) and High performance liquid chromatography (LC-20, Shimadzu, Japan) FT4 Powder Rheometer (FreemanTechnology, Tewkesbury, UK) Raw, descriptive and inferential Drug dissolution study: (i) type of dissolution media, (ii) type of polymer, and (iii) type of model drug Powder characterization: source of powder Evaluate the formulation and media compositions on the drug release profiles of different MPs Compare the difference in the powder characteristics of developed MPs and commercial excipient School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China Data is with this article
Summary
Data on the drug release profiles and powder characteristics of the ethyl cellulose based microparticles prepared by the ultra-fine particle processing system. Tingting Peng a, Yin Shi a, Chune Zhu b, **, Disang Feng a, Xiangyu Ma c, Peipei Yang a, Xuequn Bai a, Xin Pan a, Chuan-yu Wu d, Wen Tan b, Chuanbin Wu a, *
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