Abstract
Synthetic cannabinoids JWH-018, JWH-073 and AM2201 were metabolised by the fungus Cunninghamella elegans. In this article, data on individual metabolites of their retention times, mass accuracies, major product ions and structures indicated by product ions are presented. The data in this article is related to “Biotransformation of synthetic cannabinoids JWH-018, JWH-073 and AM2201 by Cunninghamella elegans” [1].
Highlights
Abusive consumption of synthetic cannabinoids that are agonists at cannabinoid CB1 receptors has been commonly reported since 2008 [1]
Product ions originating from other parts of metabolites, such as indole moiety or alkyl side chain, were analysed in the same way to deduce the whole structures of metabolites
The types of metabolic transformation detected were identical for JWH-018 and JWH-073, and they are carboxylation, dehydrogenation, dihydrodiol formation, dihydrodiol with hydroxylation, dihydrodiol with ketone formation, dihydrodiol with N-dealkylation, dihydroxylation, and hydroxylation, ketone formation, ketone formation with hydroxylation
Summary
Abusive consumption of synthetic cannabinoids that are agonists at cannabinoid CB1 receptors has been commonly reported since 2008 [1]. Sold as herbal blends or research chemicals in powder, synthetic cannabinoids mimic psychoactive effects of cannabis. Unlike cannabis some synthetic cannabinoids are reported to be full agonists and create more serious public health issues [2]. When a synthetic cannabinoid is scheduled due to increased prevalence and health concerns, new molecules with similar or even stronger psychoactive effects are synthesized by slight structural modifications to bypass the laws [3,4]. In vivo studies involving the researcher himself administering drug have been reported [5]. Despite the reliability of data obtained from such experiments, the adverse effects of these drugs are unknown and due to both health and ethical reasons it is difficult to perform in vivo human excretion studies to investigate the metabolism
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