Data of preparation and evaluation of supramolecular hydrogel based on cellulose for sustained release of therapeutic substances with antimicrobial and wound healing properties.

Adolfo Marican,Jaime Gallego,Oscar Forero-Doria,Efrain Polo,Esteban F Durán-Lara

doi:10.1016/j.dib.2020.105902

Adolfo Marican, Jaime Gallego + Show 3 more

Open Access

https://doi.org/10.1016/j.dib.2020.105902

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Journal: Data in brief	Publication Date: Jun 21, 2020
Citations: 4	License type: cc-by

Affiliation: University of Antioquia, University of Talca

Abstract

The data article refers to the paper “supramolecular hydrogel based on cellulose for sustained release of therapeutic substances with antimicrobial and wound healing properties”[1]. The dataset includes the synthesis and characterization of (E)-1,3-bis(4-(allyloxy)phenyl)prop‑2-en-1-one (3) (crosslinking agent). Moreover, the multiwall carbon nanotubes (MWCNTs) synthesis and functionalization (MWCNTs-COOH) are described. The formulation obtained by adding multiwalled carbon nanotubes-COOH with the crosslinked cellulose-chalcone hydrogel is abbreviated as MWCNTsCCH, and the same formulation loaded with therapeutic substances (TS) is named MWCNTsCCH-TS. The MWCNTsCCH database such as components and their amounts, swelling degree, thermogravimetric analysis, and cytotoxicity evaluation are depicted. Finally, to elucidate the mechanism of therapeutic substances release, the obtained averages of the release profiles were fitted through mathematical models.

Highlights

Data of preparation and evaluation of supramolecular hydrogel based on cellulose for sustained release of therapeutic substances with antimicrobial and wound healing properties
The data article refers to the paper “supramolecular hydrogel based on cellulose for sustained release of therapeutic substances with antimicrobial and wound healing properties”[1]
The formulation obtained by adding multiwalled carbon nanotubes-COOH with the crosslinked cellulose-chalcone hydrogel is abbreviated as MWCNTsCCH, and the same formulation loaded with therapeutic substances (TS) is named MWCNTsCCH-TS

Summary

Data description

The synthesis of crosslinker (E)−1,3-bis(4-(allyloxy)phenyl)prop–2-en-1-one (3) is represented in Fig. 1 and detailed description of the reaction procedure is stated in the experimental design, materials, and methods section. These data allow obtain the release profile and to calculate release kinetic of TS. This experiment was carried out to measure fibroblast cell viability after exposure to MWCNTsCCH. MWCNT were obtained through an ethanol decomposition reaction process at 900 °C in presence of perovskite-like oxide (LaFeO3) as a catalyst precursor by following the previously reported study [5].

Equilibrium swelling ratio of MWCNTsCCH

Thermogravimetric analysis

Preparation of MWCNTsCCH and loading of therapeutic substances

Drug release kinetics from MWCNTsCCH-TS

Cytotoxicity and cell viability