Abstract
As a new and preferred light source for phototherapy, blue light emitting diodes (LEDs) with wavelengths of 400–500 nm have been used to treat hyperbilirubinaemia in infantile jaundice [1]. Recent studies report that blue LED irradiation induces apoptosis by stimulating a mitochondrial pathway and reduces the early growth rate of melanoma cells in mice [2]. Here, we detected the induction of apoptotic cell death and formation of autophagosome in human B lymphoma cells after irradiation with blue LED. This paper provides data in support of the research article entitled “Blue light emitting diode induces apoptosis in lymphoid cells by stimulating autophagy” [3].
Highlights
Recent studies report that blue light emitting diodes (LEDs) irradiation induces apoptosis by stimulating a mitochondrial pathway and reduces the early growth rate of melanoma cells in mice [2]
We detected the induction of apoptotic cell death and formation of autophagosome in human B lymphoma cells after irradiation with blue LED
This paper provides data in support of the research article entitled “Blue light emitting diode induces apoptosis in lymphoid cells by stimulating autophagy” [3]
Summary
Apoptosis of blue LED-irradiated cells was detected by TUNEL staining for measuring DNA fragments and annexin V/PI staining to distinguish apoptotic and necrotic cells Jeonju, Republic of Korea. The data provide information about the effect of blue LED irradiation in B lymphoma cells. The data can be used to identify the interaction between autophagy and apoptosis. The data inform future study for application of the blue LED to kill cancer cells including lymphoma. Á , LC3 conversion and caspase activation in RAMOS cells. Irradiation with blue LED induced apoptotic cell death through autophagosome activation in RAMOS cells
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