Data from Metabolic Imaging of the Human Brain with Hyperpolarized <sup>13</sup>C Pyruvate Demonstrates <sup>13</sup>C Lactate Production in Brain Tumor Patients

Abstract

<div>Abstract<p>Hyperpolarized (HP) MRI using [1-13C] pyruvate is a novel method that can characterize energy metabolism in the human brain and brain tumors. Here, we present the first dynamically acquired human brain HP 13C metabolic spectra and spatial metabolite maps in cases of both untreated and recurrent tumors. <i>In vivo</i> production of HP lactate from HP pyruvate by tumors was indicative of altered cancer metabolism, whereas production of HP lactate in the entire brain was likely due to baseline metabolism. We correlated our results with standard clinical brain MRI, MRI DCE perfusion, and in one case FDG PET/CT. Our results suggest that HP 13C pyruvate-to-lactate conversion may be a viable metabolic biomarker for assessing tumor response.</p><p><b>Significance:</b> Hyperpolarized pyruvate MRI enables metabolic imaging in the brain and can be a quantitative biomarker for active tumors.</p><p><b>Graphical Abstract:</b> <a href="http://cancerres.aacrjournals.org/content/canres/78/14/3755/F1.large.jpg" target="_blank">http://cancerres.aacrjournals.org/content/canres/78/14/3755/F1.large.jpg</a>. <i>Cancer Res; 78(14); 3755–60. ©2018 AACR</i>.</p></div>