Abstract
<div>Abstract<p>In a genome-wide screen of 684 cancer cell lines, we identified homozygous intragenic microdeletions involving genes encoding components of the apical-basal cell polarity complexes. Among these, <i>PARD3</i> is disrupted in cell lines and primary tumors from squamous carcinomas and glioblastomas. Reconstituting <i>PARD3</i> expression in both cell types restores tight junctions and retards contact-dependent proliferation. Searching specifically for small intragenic microdeletions using high-resolution genomic arrays may be complementary to other genomic deletion screens and resequencing efforts in identifying new tumor suppressor genes. Cancer Res; 70(6); 2158–64</p></div>
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