Abstract
This data article is referred to the research article entitled Human monocyte-derived macrophages are heterogeneous: proteomic profile of different phenotypes by Eligini et al. Eligini S., Brioschi M., Fiorelli S., Tremoli E., Banfi C., Colli S. Human monocyte-derived macrophages are heterogeneous: proteomic profile of different phenotypes. J. Proteomics 124, 2015, 112-123. Macrophages obtained in vitro from blood monocytes are largely used as surrogate model of tissue macrophages that are heterogeneous and not easy to obtain and handle. Under spontaneous differentiation in vitro, monocyte-derived macrophages (MDMs) display two dominant subsets (round and spindle) that show different transcriptional, antigenic, and functional profiles mimicking, at least in part, the heterogeneity of tissue macrophages. This article reports the nano-LC-MSE analysis of the proteome of round and spindle MDMs allowing a deeper comprehension of macrophage heterogeneity.
Highlights
This data article is referred to the research article entitled Human monocyte-derived macrophages are heterogeneous: proteomic profile of different phenotypes by Eligini et al Eligini S., Brioschi M., Fiorelli S., Tremoli E., Banfi C., Colli S
This article reports the nanoLC-MSE analysis of the proteome of round and spindle monocyte-derived macrophages (MDMs) allowing a deeper comprehension of macrophage heterogeneity
Round or spindle MDMs were singly dissected by laser capture microdissection, digested with trypsin, analysed by nano-LC-MSE and processed with PLGS 2.3 (Waters Corporation, Milford, MA, USA.)
Summary
Data for proteomic analysis of Human monocyte-derived macrophages This data article is referred to the research article entitled Human monocyte-derived macrophages are heterogeneous: proteomic profile of different phenotypes by Eligini et al Eligini S., Brioschi M., Fiorelli S., Tremoli E., Banfi C., Colli S. Human monocyte-derived macrophages are heterogeneous: proteomic profile of different phenotypes.
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