Abstract
Here we describe the data provided for Problem 1 of Genetic Analysis Workshop 15. The data provided for Problem 1 were unusual in two ways. First, the phenotype was the level of gene expression for each gene, not a conventional phenotype like height or disease, and second, there were more than 3500 such phenotypes. Natural variation in gene expression was a new idea in 2004 when these data were collected and published. Because the phenotypes were measured in members of 14 Centre d'Etude du Polymorphisme Humain (CEPH) families, there was an opportunity for linkage mapping on a very large scale. For this purpose, 2882 single-nucleotide polymorphism genotypes were also provided for each family member.
Highlights
There is extensive individual variation in the expression level of many genes in organisms from yeast to humans
Study subjects The data provided to Genetic Analysis Workshop 15 (GAW15) were of several sorts
The basic collection was of data from large families, 14 three-generation Centre d'Etude du Polymorphisme Humain (CEPH) Utah families
Summary
There is extensive individual variation in the expression level of many genes in organisms from yeast to humans. The differences are smaller in monozygotic twins than among individuals of other relationships, suggesting a genetic contribution to the variation [1]. The data for Problem 1 came from studies of the genetic basis of variation in human gene expression [2,3]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
