Data for characterizing human exposure to chemicals and their contribution to human diseases: IPCHEM, HBM4EU

Abstract

Abstract Human exposure to chemicals can occur via different sources and routes. Understanding the (combined) exposure to chemicals is often hampered by a lack of data or difficulties in sharing data. This was recognized in the Commission Communication on Chemical Mixtures (252, 2012) and the Information Platform on Chemical Monitoring (IPCHEM) was developed. The aim of IPCHEM is to support a coordinated approach for collecting, storing, sharing and assessing data on the occurrence of chemicals and chemical mixtures in humans and the environment. IPCHEM covers four thematic areas to support a holistic approach to exposure assessment, including human biomonitoring, environmental monitoring, food and feed monitoring and indoor air and consumer products. The shared occurrence data support exposure assessment, the identification of sources and hot spots, the analysis of time trends and can also support the evaluation of the impact of regulatory measures to restrict exposure to specific chemicals. In particular, human biomonitoring data can provide insights into internal combined exposure, integrating across different exposure sources and routes. The ongoing EU funded project HBM4EU generates and uses human biomonitoring to assess human exposure to chemicals in Europe, to better understand the associated health impacts and to improve chemical risk assessment. Associations between chemical exposures and development of disease can be further supported using toxicological/mechanistic information to establish causal links. The presentation will focus on relevant types and sources of data available to support health impact assessments of chemical exposure.