Abstract
We present an agent-based simulation-optimization modeling framework to determine the optimal location of warehouses for the distribution of vaccines. We first extend an agent-based epidemiological simulation model of COVID-19 to capture disease transmission and forecast the number of susceptible individuals and infections. We then develop a sustainable VSC considering the impact of greenhouse gases and integrate the simulation model into the VSC model to minimize total costs and environmental impacts. We validate our proposed model using a real-world COVID-19 VSC in the US. Our findings underscore the importance of strategically managing vaccine supplies to control COVID-19 and other infectious outbreaks.
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