Abstract
An 11-year-old boy with Philadelphia chromosome positive acute lymphoblastic leukemia received dasatinib 60 mg once daily because of the resistance to imatinib. About five hours after drug administration, he developed generalized myalgia and ostealgia, lip edema and rash in the hands. An IV infusion of dexamethasone 3 mg and oral ibuprofen 200 mg were given, then the symptoms were mitigated. The above mentioned symptoms reappeared after the use of dasatinib the next day. The patient received dexamethasone and ibuprofen, the symptoms were relieved. Adverse reactions induced by dasatinib was considered. The dasatinib was stopped. Two days later, the patient received dasatinib at the same dosage as before and intensive treatment with vindesine, idarubicin, pegaspargase and dexamethasone, no symptoms recurred. Key words: Dasatinib; Drug toxicity
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