Abstract
Site-specific proteolytic processing is an irreversible post-translational protein modification with essential regulatory functions. Dedicated methods enable proteome-wide characterization of differentially processed proteoforms based on their distinct protease-generated N termini. Exemplary profiling of murine glomeruli revealed processed forms of proteins with important functions in the renal filtration barrier. Altered processing was observed in cellular and animal models of glomerular disease.
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Schedule a callMore From: Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)
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