Das „feedback loop model“ – ein neues hypothetisches Modell zur frühen Karzinogenese

Abstract

The classical somatic mutation theory of carcinogenesis and metastases (SMT) explains malignant transformation by incidence of mutations in oncogenes or tumor suppressor genes. These mutations lead to a cell-autonomous activation and thereby growth advantage compared to neighbouring cells. However, this SMT does not seem fit to completely explain many characteristics of carcinomas. Contrary to the cell centered view on carcinogenesis of the SMT, research recently showed more and more evidence that the tumor microenvironment is involved in carcinogenesis, too.