Das Bindegewebswachstum in subcutan implantierten Kunststoffschwämmchen bei der Ratte

Abstract

Small polyester-polyurethane-sponges were implanted subcutaneously into rats 3, 6 and 12 months of age, and the connective tissue grown into these sponges was studied 6 hours up to 15 months after implantation morphologically and by autoradiography. The 6x12 mm cylindrical sponges were completely filled up by the newly formed connective tissue 5–9 weeks after implantation. Until that time the connective tissue develops uniformly. Thereafter there is still a cell renewing in all age groups, but the further differentiation of the connective tissue is very inhomogeneous. The formation of scar tissue begins earlier and develops more rapidly in the older animals than in the younger ones. 15 months after implantation only in the oldest age group a nearly complete scar tissue has developed. At the beginning of the differentiation-phase small areas of fat cells are present in the periphery of the sponges that expand more extensively in the older animals than in the young ones. 7 1⧀v2-14 months after implantation foreign body sarcomas had developed in two animals of the oldest age group and in one animal 6 months of age at the beginning of the investigation. One animal showed metastases of the lungs. Bone formation was found in one of the oldest rats one year after implantation.