Darstellung von (9-β-ᴅ-Ribofuranosyl)-s-triazolo-[ 1,2a]-purin-6-on durch Cyclisierung von N-1-Aminoguanosin / Preparation of (9-β-ᴅ-Ribofuranosyl)-s-triazolo-[1,2a]-purine-6-one by Cyclization of N-1-Amino Guanosine

Abstract

I report on the preparation of (9-β-ᴅ-ribofuranosyl)-s-triazolo-[1,2a]-purine-6-one (2) by cycli- zation of N-1-amino guanosine (1) with formamide. The tricyclic nucleoside analogue was charac­terized by NMR-spectroscopy (1H-NMR; 13C-NMR). The utility of 2 for the introduction of “cross­links” in double stranded nucleic acids is discussed.