Darstellung 2‐methoxysubstituierter Pyrrole durch intramolekulare Aza‐Wittig‐Reaktionen

Abstract

Preparation of 2‐Methoxy‐Substituted Pyrroles by Aza‐Wittig Reactionsα‐Halo ketones and dimethyl malonate can be transformed by Knoevenagel condensation and nucleophilic displacement of halogen with sodium azide into the azide esters 10. These azides undergo ring closure to 2‐methoxy‐substituted pyrroles 11 by intramolecular Aza‐Wittig reaction.