Abstract
Using sodium aspartate Ringer's and isolated frog retinas we have recorded gross potentials from the frog's 502 (rhodopsin) rods. Substantial dark adaptation is seen at the receptor in the isolated retina in which little or no rod pigment regeneration occurs. Lights that bleach only a fraction of a per cent of rod pigment substantially decrease rod sensitivity, but sensitivity quickly returns to the prebleach level. With lights that bleach measurable amounts of pigment, the rods recover their sensitivity more slowly and show a permanent loss in sensitivity.
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