Dark Adaptation as a Model of the Parkinsonian Visual System

Abstract

It has been suggested that the Parkinsonian visual system is like the normal visual system, but is inappropriately dark-adapted (Beaumont et al, 1987 Clinical Vision Sciences2 123 – 129). Thus it is of interest to ask to what extent dark adaptation of normal subjects produces visual changes like those of Parkinson's disease (PD). One such change is the reduction in apparent contrast of medium and high spatial frequencies in peripheral vision in the illness (Harris et al, 1992 Brain115 1447 – 1457). Normal subjects judged whether the contrast of a peripherally viewed grating was higher or lower than that of a foveally viewed grating, and a staircase technique was used to estimate the point of subjective equality. Judgements were made at four spatial frequencies (0.5 to 4.0 cycles deg−1) and four contrasts (8.0% to 64%). The display, the mean luminance of which was 26 cd m−2, was viewed through a 1.5 lu nd filter in the relatively dark-adapted condition. The ANOVA showed an interaction between dark adaptation and the spatial frequency of the gratings. Dark adaptation reduces the apparent contrast of high-spatial-frequency gratings, an effect which is greater at lower contrasts. This mimics the effect found with PD sufferers, and suggests that dark adaptation may provide a useful model of the PD visual system. In a second experiment, the effect of dark adaptation on the relationship between apparent spatial frequency in the fovea and periphery was investigated. The experiment was similar to the first, except that judgements were made about the apparent spatial frequency, rather than the contrast, of the peripheral grating. ANOVA showed no differential effect of dark adaptation on the apparent spatial frequency of the peripheral grating. This suggests that the observed reduction in apparent contrast of the peripheral gratings in dark-adapted normals and Parkinson's sufferers may reflect relative changes in contrast gain, rather than relative changes in the spatial organisation of receptive fields.