Abstract
The effectiveness of daptomycin versus vancomycin for treating experimental methicillin-susceptible (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) catheter-related infection by antibiotic-lock technique was assessed. One MSSA strain and one clinical MRSA isolate were used. A preliminary invitro study determined the minimum biofilm eradication concentration (MBEC) of vancomycin and daptomycin. An intravenous catheter was implanted in New Zealand white rabbits. Infection was induced by 24h locking the catheter with 0.3mL of broth culture containing MSSA or MRSA. The 24h of antibiotic-lock treatment groups were: control, vancomycin 10mg/mL, daptomycin 5mg/mL and daptomycin 50mg/mL. Daptomycin showed greater invitro activity than vancomycin against biofilm bacteria (MBECs of vancomycin and daptomycin for MSSA, >2000mg/L and 7mg/L; MRSA, >2000mg/L and 15mg/L). Daptomycin 5mg/mL achieved significant reductions relative to vancomycin 10mg/mL in log10cfu recovered from catheter tips for both strains (P<0.05). Only daptomycin 50mg/mL achieved negative catheter tip cultures (up to 75% in MSSA and 85% in MRSA, P<0.05), showing the greatest median log10cfu reduction compared to controls (6.07 in MSSA and 6.59 in MRSA, P<0.05). Daptomycin 50mg/mL showed the highest activity against both strains biofilms.
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