Abstract
Acetylation of dapsone (DDS) and sulfamethazine (SMZ), and plasma clearance of DDS were studied in Malaysian Chinese with lepromatous leprosy including 40 DDS-resistant and 44 non-resistant patients. Neither a patient's acetylation characteristics (DDS or SMZ), nor his plasma clearance rate, appeared to have predisposed him to the development of DDS resistance. A potentially important drug interaction between rifampin and DDS was discovered. After ingestion of rifampin for a minimum of 2 weeks, the plasma clearance of DDS was increased and the relative amount of the acetylated DDS was decreased. The implications of these results for the treatment of lepromatous leprosy are discussed.
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