Abstract
The present study was designed to investigate the function of death-associated protein kinase 1 (DAPK1) in infantile pneumonia and explore the potential mechanism of the actions. Male C57BL/6 mice were injected with 2 mg/kg of LPS for the mice model of infantile pneumonia. A549 cells were treated with 100 ng/ml of LPS for vitro model of infantile pneumonia. Dapk1 mRNA and protein expressions in 6, 12 or 24 h after induction model of mice. Dapk1 gene increased inflammation in vitro model through activation of p38MAPK-mediated NF-κB expression. The inhibition of p38MAPK or NF-κB reduced the pro-inflammation effects of DAPK1 in infantile pneumonia. Our study demonstrates that Dapk1 promoted inflammation of infantile pneumonia by p38MAPK/NF-κB signaling pathway, may be achieved inflammation by activation of p38MAPK/NF-κB signaling pathway.
Highlights
Mycoplasmal pneumonia is a respiratory infection caused by mycoplasma pneumoniae, which is clinically manifested by fever, cough, sputum expectoration, anorexia, headache, sore throat, substernal pain and chills [1]
Our study demonstrates that Dapk1 promoted inflammation of infantile pneumonia by p38MAPK/NF-κB signaling pathway, may be achieved inflammation by activation of p38MAPK/NF-κB signaling pathway
We used vitro model to analyze the effects of Dapk1 gene on infantile pneumonia
Summary
Mycoplasmal pneumonia is a respiratory infection caused by mycoplasma pneumoniae, which is clinically manifested by fever, cough, sputum expectoration, anorexia, headache, sore throat, substernal pain and chills [1]. The more atypical clinical symptoms are generally detected in younger children, often accompanied with multi-system and multi-organ functional damage [2]. Infantile mycoplasmal pneumonia is one of the main causes of respiratory infection in children [2]. The etiology of infantile pneumonia is not completely clear, which might be associated with the humoral and cellular immunity of the children [3]. Anti-infection and symptomatic treatment are the main therapeutic approaches. The present study was designed to investigate the function of Death associated protein kinase 1 (DAPK1) in infantile pneumonia and explore the potential mechanism of the actions
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