Dapivirine Vaginal Ring Showed Modest Efficacy at Preventing HIV Infection in African Women

Abstract

Preexposure prophylaxis with antiretroviral therapy can lower risk for HIV acquisition, but the efficacy of this approach depends on adherence to daily use of medication (e.g., in vaginal gel). To assess the efficacy of a vaginal ring containing dapivirine, a nonnucleoside reverse-transcriptase inhibitor, investigators randomized 1959 women in South Africa and Uganda to dapivirine-containing or placebo rings changed every …