Abstract
IntroductionSince the beginning of the cardiac surgery with cardiopulmonary bypass, myocardial-reperfusion injury has been recognized as one of the leading causes of morbidity and mortality related with this type of surgery. MethodologyA bibliographic review in Pubmed and other data base including Teseo has been carried out. ResultsFundaments of the cellular changes during the ischemic time, cellular changes in the reperfusion time, release of oxygen free radicals, complement activation, proinflammatory cytokines activation and neutrophil-endothelium interaction are exposed. A table with a selected list of drugs and compounds used against the myocardial ischemic -reperfusion injury syndrome is included. ConclusionsAt present, the myocardial reperfusion injury syndrome is an active line of research. There are many trials and studies on investigating new agents .The cardiac surgeon should be well informed in new strategies in myocardial protection in cardiac surgery.155 words
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