Abstract
Ventricular refibrillation frequently occurs after successful defibrillation of Ventricular Fibrillation (VF) and negatively affects the outcomes. Sustained elevation in cytosolic calcium and dysfunction in intracellular calcium handling has been proposed to underlie post-shock arrhythmias in rabbit hearts. Ryanodine Receptor 2 (RyR2) is the major calcium handling protein in cardiomyocytes and its dysfunction causes diastolic calcium leak from sarcoplasmic reticulum and calcium transient amplitude alternans (Ca-Alt), which can result in arrhythmias. We hypothesized that Dantrolene protects against refibrillations by restoring cardiac calcium handling and stabilizing RyR2 after VF.
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