Danggui-Yimucao Herb Pair Can Protect Mice From the Immune Imbalance Caused by Medical Abortion and Stabilize the Level of Serum Metabolites.

Shi-Jie Bi,Rui-Jia Fu,Li-Mei Feng,Ding-Qiao Xu,Shi-Jun Yue,Xue Bai,Yu-Ping Tang,Sai Zhang

doi:10.3389/fphar.2021.754125

Shi-Jie Bi, Rui-Jia Fu + Show 6 more

Open Access

https://doi.org/10.3389/fphar.2021.754125

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Abstract

Unintended pregnancy is a situation that every woman may encounter, and medical abortion is the first choice for women, but abortion often brings many sequelae. Angelica sinensis Radix (Danggui) and Leonuri Herba (Yimucao) are widely used in the treatment of gynecological diseases, which can regulate menstrual disorders, amenorrhea, dysmenorrhea, and promote blood circulation and remove blood stasis, but the mechanism for the treatment of abortion is not clear. We determined the ability of Danggui and Yimucao herb pair (DY) to regulate the Th1/Th2 paradigm by detecting the level of progesterone in the serum and the expression of T-bet and GATA-3 in the spleen and uterus. Then, we detected the level of metabolites in the serum and enriched multiple metabolic pathways. The arachidonic acid pathway can directly regulate the differentiation of Th1/Th2 cells. This may be one of the potential mechanisms of DY in the treatment of abortion.

Highlights

Unintended pregnancy is a situation that all women may encounter
Studies showed that Th1/Th2 was involved in both the maintenance of pregnancy and abortion (Saito et al, 2010; He et al, 2018a)
Th2 cells and cytokines were dominant, which might be progesterone could inhibit the differentiation of Th1 but enhance the differentiation of Th2, so that Th1/Th2 balance tended to Th2 (Sykes et al, 2012a; Ahmadi et al, 2017)

Summary

Introduction

Since 2015, there was an average of 121 million unintended pregnancies per year, which was equivalent to a global rate of 64 unintended pregnancies per 1,000 women aged 15–49 each year. Over this period, there was an average of 73.3 million abortions per year, which corresponded to a rate of 39 abortions per 1,000 women worldwide each year. There was an average of 73.3 million abortions per year, which corresponded to a rate of 39 abortions per 1,000 women worldwide each year These statistics indicate that 61% of unintended pregnancies end up with abortions (Bearak et al, 2020). The experience of abortion may increase the possibility of spontaneous abortion in the future, the more abortions there are, the higher the risk of spontaneous abortion (Virk et al, 2007; Nigro et al, 2011)

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