Abstract
Dangerous Membranes: Viruses That Subvert Autophagosomes
Highlights
In the early days of the virus-autophagy field, two non-exclusive theories were advanced about the relationship between infection and autophagosome formation
A major topology problem remains: namely, how might a virus transverse multiple lipid bilayers to be released from cells without a surrounding membrane? Recent papers have indicated that picornaviruses, including Hepatitis A Virus and Coxsackievirus B3, are often released in membranous vesicles and are not purely non-enveloped
A pair of recent papers in the Journal of Virology introduced the idea of a functional relationship between the autophagy pathway and Epstein–Barr Virus (EBV)
Summary
In the early days of the virus-autophagy field, two non-exclusive theories were advanced about the relationship between infection and autophagosome formation. At the time, no evidence that such a pathway existed, it was later shown that autophagy does feed into non-canonical cellular secretion. A major topology problem remains: namely, how might a virus transverse multiple lipid bilayers (two on the autophagosome, and one on the plasma membrane) to be released from cells without a surrounding membrane?
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