Abstract
Two new bromopyrrole alkaloids, damipipecolin ( 1) and damituricin ( 2), have been isolated from the Mediterranean sponge Axinella damicornis, and their structures established through spectroscopic methods. Compounds 1 and 2 extend the structural variety of the so far known pyrrole alkaloids; in these compounds, the 4-bromopyrrole 2-carboxylic acid is directly condensed with a non-protein cyclic α-amino acid, the (2 R, 4 R)- trans-4-hydroxypipecolic acid and (2 R, 4 R)- cis- N, N′-dimethyl-4-hydroxyproline ( d-turicine) in 1 and 2, respectively. Compounds 1 and 2 were found to display a modulating effect of the serotonin receptor activity in vitro.
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