Damage to the digestive tract of monogastric animals by “hot” radioactive particles

Abstract

For the first time, the dosimetric characteristics of the gastrointestinal tract damaged of the monogastric animals (rats, guinea pigs, pigs) due to peroral ß-irradiation that cause ulcerative lesions of the gastrointestinal tract are presented. The main factors in the formation of such ulcerative lesions are the uneven distribution of particles in the contents of the digestive tract (DT), the concentration of particles in certain areas of the mucous membrane, followed by the formation of local radiation levels that exceed the average values of absorbed doses by more than 3 times. Clinical manifestations of irradiation with a pathoanatomic assessment of the process of ulcer formation made it possible to classify the disease as radiation ulcerative gastroenterocolitis and distinguish extremely severe, severe, medium and mild degrees depending on the amount of incoming activity of “hot” radioactive particles and absorbed doses of ionizing radiation formed in the DT.