Abstract
The molecular background of toxic properties of phenoxy herbicides for humand and animals is insufficiently studied. In this study, damage parameters (hemolysis, hemoglobin oxidation, and lipid peroxidation) were measured in human erythrocytes exposed to several commonly used herbicides from this group (2,4-D, 2,4,5-T, and MCPA) and their phenolic metabolites. For all parameters studied the impact of herbicide metabolites was stronger than that of herbicides themselves. The extent of hemolysis was dose-dependent and also depended on the solvent used. Whereas compounds with methyl groups were more potent in the methemoglobin formation assay, compounds with chlorine substituents caused higher lipid peroxidation.
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