Abstract
Studies have shown that supplementation with extracts from various sources, including fruits and vegetables reverse the age-related changes in movement and cognition. We hypothesized that these beneficial effects result from the presence of anti-oxidants and anti-inflammatory compounds in the fruits and vegetables that contribute to reduced oxidative stress, inflammation and cell death while potentially enhancing neurogenesis. The present study was performed to determine the impact of supplementation with GrandFusion®(GF) to aged Fisher 344 rats for 4 months to determine the impact on attenuation or reversal of the age-related deficits. When the aged rats consumed a diet enriched with the extracts the results showed an improved motor performance, and enhanced cognitive functions. In addition, the rats showed reduced oxidative stress and inflammation, and enhanced neurogenesis, Nrf2 and anti-oxidant expression. The effect of GF extracts on the augmentation of memory and learning is significant and may function through the modulation of antioxidant enzymes, signaling pathways and additional mechanisms to improve the aging process. These studies further support the recommendation of USDA for the consumption of fruits and vegetables to improve healthy aging.
Highlights
Aging is a multifaceted process that results in increases in inflammation, oxidative stress (OS) and contributes to cellular senescence, eventually leading to a decline in organ function and death [1,2,3,4]
There were no significant differences in food consumption between the control rats and the rats on the GF diets
The current study has shown that a diet enriched with GrandFusion® can reduce inflammation and oxidative stress, neural stem cell proliferation and improved cognitive function in the aged rat brain
Summary
Aging is a multifaceted process that results in increases in inflammation, oxidative stress (OS) and contributes to cellular senescence, eventually leading to a decline in organ function and death [1,2,3,4]. A decrease in endogenous antioxidant mechanisms with aging increases the vulnerability of the brain to oxidative damage as a result of exacerbated OS [7]. Aging results in an increase in inflammatory mediators (i.e., cytokines, chemokines, etc.) liberated by microglia and astrocytes in the brain and an infiltration of peripheral inflammatory cells that contribute to the cognitive and physical deficits [9]. These changes in OS and inflammation result in alteration in membrane structure, modifications in DNA, RNA, protein and lipids that contribute to age-related adjustments in brain vulnerability [10,11]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
