Abstract
AbstractPurpose To investigate visual perception of previously blind retinitis pigmentosa (RP) patients using electronic subretinal implants.Methods The new Alpha IMS chip (Retina Implant AG) with its 1500 photodiodes, amplifiers and electrodes powered wirelessly via a subdermal coil was implanted subretinally in 7 retinitis pigmentosa patients for indoor and outdoor use.Results VA was up to 21/1000 within a field of 11° by 11° (see previous pilot study http://rspb.royalsocietypublishing.org/content/early/2010/11/01/rspb.2010.1747). A) Near vision: Localizing, cutlery and tableware, plates and content in 4AFC mode and in restaurants, facial characteristics of persons, items on working desk. B) Far vision: Recognizing clouds, clothes of people, borders of cars by metallic reflections, discerning smaller from larger persons. C) Spatial resolution: Position of clock hands, stripe patterns up to approx. 0.33 – 0.44 cpd, reading letters 4 to 8 cm high, localization and recognition of square, round or rectangular objects . D) Contrast: Differentiation of 7 to 10 shades of grey; increased sensitivity for infrared radiation. E) Motion: Hand movement, walking direction of a goose, circumvention of obstacles. F) Eye‐hand coordination: Pointing at objects and moving them.Conclusion Subretinal Alpha IMS implants allow RP‐ patients within few days of exercising to localize objects and to perform visuomotor tasks for improved orientation and mobility. This device thereby can provide considerable support to blind RP patients in mastering tasks of daily life, indoor and outdoor, as shown in an ongoing clinical study. Commercial interest
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