Abstract
Circadian rhythmicity was investigated in isolated small intestine and mucosal epithelial cells from rats on restricted-feeding regimen (food available from 17:00 to 23:00 every day). In the isolated intestine, daily rhythms synchronized to meal-timing were found in the activity patterns of l-leucine, l-lysine and d-glucose transport, and mucosal γ-glutamyltransferase and sucrase, and in the rates of lactate formation from glucose; the nadirs occurred at 12:00 and the peaks at 23:00. These same patterns were also noted with the mucosal epithelial cells prepared at distinct times of day from rats on meal-feeding regimen. The fasted rat intestine responded to refeeding with prompt increase in transport activity, i.e., out of phase with the original rhythm. Intraperitoneal administration of cyloheximide suppressed the daily rise in leucine transport activity, indicating that the transport rhythm was entrained by or closely associated with the rhythmic fluctuation in protein synthesis in the epithelial cells,...
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