Abstract
Maternal plasma lipids are elevated during pregnancy. Early pregnancy dyslipidemia is associated with an increased risk of preeclampsia. Physical activity improves lipid profiles in non-pregnant adults. PURPOSE: To determine the relationship between lipid profiles of pregnant women at risk for preeclampsia and their daily physical activity levels. METHODS: The sample for this analysis was drawn from participants of the ongoing study designed to determine the effect of regular exercise on the incidence of preeclampsia. The study sample is comprised of 70 sedentary pregnant women with a past medical history of preeclampsia. From structured questionnaires and medical records, we obtained information including maternal age, ethnicity, education, height and weight and physical activity at 18 weeks gestation (at the time of blood collection). Plasma lipid concentrations were measured enzymatically by standardized assays. Daily physical activity levels were classified into 3 groups: leisure time physical activity (LTPA), domestic activity (DA) and occupational activity (OA). Protocols were approved by the IRB at each institution. RESULTS: Study sample (n=70) was comprised of mainly Caucasian (80%) and 60% had at least college education (age: 31.2 +/− 3.8). Women with high OA level had 18.0% higher concentration of HDL cholesterol than women with a low OA level (73.5 +/− 3.1 vs. 62.3 +/−4.7 mg/dL, p=0.046). Remainder lipid categories were not significantly correlated with any other physical activities. A significant increase in the odds of having higher HDL concentration (<63.5 mg/do) was observed among women with high OA level compared to women with low OA level (OR=4.87, 95% CI 1.06 to 22.38). CONCLUSION: These analyses suggest that women with a sedentary lifestyle but physically involved work life may have a favorable cholesterol profile in early pregnancy. Further studies are needed to examine the overall physical activity during pregnancy and risk of preeclampsia. (Funded by RO1 NR05002; NIH)
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