Abstract
Recently there has been growing evidence on the involvement of gonadal hormones and their changes, in the pathophysiology of menstrually related mood changes. For monitoring daily fluctuation in levels of these hormones, plasma single-point determination is probably not representative due to the episodic nature of secretion and 24-h urine collections are too cumbersome for long monitoring periods. Determinations of urinary gonadal glucuronides in a first morning void might overcome both these drawbacks. We compared urinary first morning void estrogen glucuronides and pregnanediol glucuronide, to their homologues in plasma, estradiol and progesterone, during the entire menstrual cycle as well as during shorter periods of greater fluctuation in order to determine applicability of this method. Correlation between plasma levels of estradiol and progesterone and first morning urine levels of estrone glucuronide and pregnanediol glucuronide was highly significant for the whole menstrual cycle. The correlation b...
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