Abstract
Daily lifestyle is a fundamental part of human life and its influence accumulates daily in the human body. We observe that a good daily lifestyle has a beneficial impact on our health; however, the actual effects of individual daily lifestyle factors on human skin diseases, especially skin cancers, have not been summarized. In this review, we focused on the influence of daily lifestyle on the development of skin cancer and described the detailed molecular mechanisms of the development or regulation of cutaneous malignancies. Several daily lifestyle factors, such as circadian rhythm disruption, smoking, alcohol, fatty acids, dietary fiber, obesity, and ultraviolet light, are known to be associated with the risk of cutaneous malignancies, malignant melanoma, squamous cell carcinoma, basal cell carcinoma, and Merkel cell carcinoma. Although the influence of some daily lifestyles on the risk of skin cancers is controversial, this review provides us a better understanding of the relationship between daily lifestyle factors and skin cancers.
Highlights
Human beings are constantly exposed to various environmental stimuli and have developed their ability to adapt to these external factors, such as circadian rhythm, food intake, ultraviolet light, and microorganisms [1,2,3]
PER1 is decreased in squamous cell carcinoma [63,64] and low expression of PER1 is closely related to unfavorable clinical behavior, such as developed lymph node metastasis and advanced clinical stage [64,65], and poor survival [66]
Omega-3 fatty acids decrease the risk of melanoma, squamous cell carcinoma, and basal cell carcinoma, and omega-6 fatty acids increase the risk of melanoma and squamous cell carcinoma
Summary
Human beings are constantly exposed to various environmental stimuli and have developed their ability to adapt to these external factors, such as circadian rhythm, food intake, ultraviolet light, and microorganisms [1,2,3]. Among these environmental factors on Earth, daily lifestyle is a fundamental part of human life and influences human health. The influence of lifestyles, such as dietary foods and luxury consumptions, accumulates daily and affects human health [4,5,6] These influences are helpful information for clinicians to understand the detailed molecular pathogenesis of daily lifestyle-related human diseases. This review only focused on major daily lifestyle factors, including UV irradiation
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