Daily ingestion of catechin-rich beverage increases brown adipose tissue density and decreases extramyocellular lipids in healthy young women.

Shinsuke Nirengi,Saori Matsumiya,Takeshi Yoneshiro,Takafumi Hamaoka,Toshiyuki Homma,Masayuki Saito,Naoki Sakane,Kumiko Ebi,Shiho Amagasa,Yuko Kurosawa

doi:10.1186/s40064-016-3029-0

Abstract

PurposeBrown adipose tissue (BAT) contributes to the regulation of non-shivering thermogenesis and adiposity. Increasing BAT has recently attracted much attention as a countermeasure to obesity. Animal studies have shown that prolonged catechin treatment increases uncoupling protein 1, a thermogenic protein in BAT. On the other hand, supportable evidence in human is lacking. Thus, the purpose of this study was to examine whether BAT increases after catechin ingestion in humans.MethodsTwenty-two healthy young women were given either a catechin-rich (540 mg/day; catechin) or placebo beverage every day for 12 weeks in a double-blind design. BAT density was measured using near-infrared time-resolved spectroscopy (NIRTRS), visceral fat area were measured using magnetic resonance imaging, extramyocellular lipids (EMCL) using proton magnetic resonance spectroscopy, and body fat mass using dual-energy X-ray absorptiometry scans.ResultsBAT density was significantly increased (18.8 %), and EMCL was decreased (17.4 %) after the 12-week ingestion. There was a significant negative correlation between the changes in BAT density and those in EMCL (r = −0.66, P < 0.05). There were no notable changes in other parameters.ConclusionsIn conclusion, prolonged ingestion of a catechin-rich beverage increases the BAT density in parallel with a decrease in EMCL.

Highlights

Brown adipose tissue (BAT) produces heat during cold exposure and spontaneous overfeeding via upregulation of uncoupling protein 1 (UCP-1), whereas white adipose tissue stores excess energy as triglycerides in mammals (Cannon and Nedergaard 2004)
*Correspondence: kyp02504@nifty.com †Shinsuke Nirengi, Shiho Amagasa, Toshiyuki Homma, Takeshi Yoneshiro, Saori Matsumiya, Yuko Kurosawa, Naoki Sakane, Kumiko Ebi, Masayuki Saito and Takafumi Hamaoka contributed to this work 6 Department of Sports Medicine for Health Promotion Tokyo Medical University, 6‐1‐1 Shinjuku, Shinjuku‐ku, Tokyo 160‐8402, Japan Full list of author information is available at the end of the article metabolically active BAT has been identified in the supraclavicular and paraspinal regions in radionuclide studies using 18F-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/ CT) (Cypess et al 2009; Saito et al 2009; van Marken Lichtenbelt et al 2009; Virtanen et al 2009)
We measured following parameters for participants in both groups at baseline and after 12 weeks of intervention during the luteal phase predicted from menstrual cycle and last menstrual period: BAT density, body composition, visceral fat area (VFA), subcutaneous fat area (SFA), skinfold thickness, circulatory parameters [systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR)], and intramyocellular lipid (IMCL) and extramyocellular lipid (EMCL) concentrations

Summary

Introduction

Brown adipose tissue (BAT) produces heat during cold exposure and spontaneous overfeeding via upregulation of uncoupling protein 1 (UCP-1), whereas white adipose tissue stores excess energy as triglycerides in mammals (Cannon and Nedergaard 2004). Nirengi et al SpringerPlus (2016) 5:1363 due to the limitations of FDG-PET/CT, such as radiation exposure, it is difficult to conduct longitudinal intervention studies on the effects of an increase in the amount of BAT in humans. The [total-Hb] under thermoneutral conditions was positively correlated with BAT activity (SUVmax) estimated by FDGPET/CT in the supraclavicular region, which potentially contains BAT deposits (r = 0.73) (Nirengi et al 2015). Considering the abundant vascularity of BAT compared with that of other tissues, our results suggest that [totalHb] estimated by NIRTRS provides BAT density at the approximately 4-cm tissue (Nirengi et al 2015). Our new longitudinal study reported that the [total-Hb] increases with the increasing in the SUVmax evaluated by FDG-PET/CT during repeated thermogenic capsiate intake, which is known to increase BAT activity and mass. The amplitude of the increment of [total-Hb] (46.4 %) and SUVmax (48.8 %) is equivalent (Nirengi et al 2016), confirming the validity of our measurements in longitudinal experimental setups

Objectives

Methods

Results

Discussion

Conclusion