Daily Fluctuation of Facial Pore Area, Roughness and Redness among Young Japanese Women; Beneficial Effects of Galactomyces Ferment Filtrate Containing Antioxidative Skin Care Formula.

Kukizo Miyamoto,Bandara Dissanayake,Masaki Takemura,Gaku Tsuji,Masutaka Furue,Tatsuya Omotezako

doi:10.3390/jcm10112502

Kukizo Miyamoto, Bandara Dissanayake + Show 4 more

Open Access

https://doi.org/10.3390/jcm10112502

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Abstract

Young women often complain about the daily fluctuation of their facial skin conditions. However, no objective study has been carried out on such changes. This study is aimed at quantitatively elucidating daily skin fluctuation and evaluating the efficacy of cosmetic skin care treatment. We developed the first portable and self-guided facial skin imaging device (eMR Pro) to reproducibly capture facial images at home. Two 8 week clinical studies were then conducted to analyze daily skin fluctuation of facial pore areas, roughness and redness in young Japanese women (n = 47 in study 1 and n = 57 in study 2) by collecting facial images three times a day, during the morning after wake-up, during the morning after face wash, and during the evening after face wash. After a 4 week baseline measurement period (week -4 to week -1), all subjects applied Galactomyces ferment filtrate (GFF, Pitera®) skin care formula twice a day for 4 weeks (week 1 to week 4). These three skin conditions did exhibit different fluctuation patterns. The pore area and roughness showed the “morning after wake-up”-largest fluctuation pattern, whereas redness showed the “evening after face wash”-largest fluctuation pattern. GFF treatment significantly reduced the net values and delta fluctuation of pore area, roughness, and redness, which were consistently observed in two studies. In conclusion, the daily fluctuation of facial skin conditions is potentially a new target field for investigating healthy skin maintenance.

Highlights

It is important to maintain the homeostasis of epidermal bioavailability and structural functions for healthy and stress-tolerant skin with a youthful appearance
We reported that skin moisturization is critical for a youthful appearance in a 10 year longitudinal skin aging study in Akita, Japan [6]
In the baseline measurement period from week -4 to week -1, pore areas were significantly larger during the morning after of 13 wake-up than those during the morning after face wash or during the evening6 after face wash in both Studies 1 and 2 (Figure 4 and Supplementary Table S1 in Supplementary Materials)

Summary

Introduction

It is important to maintain the homeostasis of epidermal bioavailability and structural functions for healthy and stress-tolerant skin with a youthful appearance. We reported that skin moisturization is critical for a youthful appearance in a 10 year longitudinal skin aging study in Akita, Japan [6]. 20–35 years demonstrated that the top three facial concerns are enlarged follicular pores, dryness/rough texture, and facial color (redness and spots). These young adult women complain that their facial condition fluctuates daily or weekly in their usual life. There are no studies that address the variation or fluctuation of facial skin appearance

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