Abstract
The objective of this study was to evaluate cortisol in the saliva and serum of healthy persons and its daily fluctuations by using immunochemical method on a autoanalyzer. Biological samples: Serum from 14 healthy persons and saliva from 18 healthy persons were taken two times at 8 a.m. and at 4 p.m. Immunochemical assay: The principle of this method is the competitive binding of cortisol present in the analyzed sample and cortisol marked with peroxides on binding parts with specific antibodies. Student t-test. Cortisol in saliva in the morning: 21,2 +/- 16,2 nmol/l and in the afternoon 12,7 +/- 8,1 nmol/l. Cortisol in serum in the morning: 459, 6 +/- 235,2 nmol/l , and in the afternoon 340,5 +/- 207,5 nmol/l. The concentrations of cortisol in saliva are lower than in serum. Cortisol in the serum in the morning is about twenty times higher than cortisol in the saliva at the same time. Cortisol in the serum at afternoon is about twenty-seven times higher than cortisol in the saliva. Individual variabilities of cortisol in the saliva and serum were found during the day.
Highlights
Cortisol is the main glucocorticoid hormone which is secreted by the cortex of the adrenal gland
Results show that concentration of cortisol in saliva is statistically much higher in the morning, than it is in the after noon (p
Synthesis and secretion of cortisol are controlled by adenohypophysis hormone, adrenocorticotropin hormone, ACTH, while the synthesis and secretion of ACTH is controlled by hypothalamus hormone, corticotrophin releasing hormone, CRH
Summary
Cortisol is the main glucocorticoid hormone which is secreted by the cortex of the adrenal gland. According to its chemical structure, cortisol is a steroid hormone. Cortisol affects the metabolism of carbohydrates, fats and proteins. Cortisol is involved in the response to stress and is necessary for the proper functioning of an organism. The adrenal gland cortex secretes the group of different hormones called corticosteroids. According to its leading physiological influence, corticosteroids can be divided into three groups: glucocorticoids (cortisol and corticosteron), mineral corticoids (aldosteron), and androgen hormones (dehydroepiandrosteron and androstenedion). Like all other adrenal gland cortex hormones, comes from cholesterol
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