Abstract
The bedaquiline regimen for the treatment of multidrug-resistant tuberculosis (MDR-TB) in adults is a loading dose of 400 mg QD for 2 weeks followed by 200 mg thrice weekly (TIW) for 22 weeks. Most TB antibiotics administered with bedaquiline are given QD. Using pharmacokinetic simulations, we explored alternative QD bedaquiline regimens and determined that 200 mg QD for 8 weeks followed by 100 mg QD provides comparable exposures to the approved regimen. This simpler regimen is under clinical evaluation.
Highlights
Daily Dosing for Bedaquiline in Patients with TuberculosisNedelman,b Carl Mendel,b Melvin Spigelman,b David J
The bedaquiline regimen for the treatment of multidrug-resistant tuberculosis (MDR-TB) in adults is a loading dose of 400 mg QD for 2 weeks followed by 200 mg thrice weekly (TIW) for 22 weeks
● 400 mg QD for 14 days followed by 200 mg TIW
Summary
Nedelman,b Carl Mendel,b Melvin Spigelman,b David J. Hermannc aCertara, Inc., under contract with the Bill and Melinda Gates Foundation, Seattle, Washington, USA bTB Alliance, New York, New York, USA cBill and Melinda Gates Foundation, Seattle, Washington, USA
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