Abstract
Daily Consumption of Angelica Keiskei Juice Attenuated Hyperlipidaemia and Hepatic Steatosis Caused by Western Diet in C57BL/6J Mice
Highlights
Angelica keiskei, commonly known as Ashitaba, is a cold hardy perennial plant in the genus of Angelica
High-dose Angelica keiskei juice (AK) was effective in maintaining intestinal barrier integrity and increasing mRNA expression of hepatic nuclear factor erythroid 2-related factor 2 (P=0.003)
It tended to modify mRNA expressions of intestinal lipoprotein lipase (P=0.004), and hepatic carnitine palmitoyl transferase 1α (P=0.038), endoplasmic reticulum nuclei-1 (P=0.014), and NAD(P)H: quinone oxidoreductase 1 (P=0.047). These findings suggest that daily consumption of AK juice may have potentials to prevent Western diet (WD)-induced non-alcoholic fatty liver disease (NAFLD) development through mitigating intestinal barrier damage, intestinal lipid absorption, and hepatic ER oxidative stress
Summary
Commonly known as Ashitaba, is a cold hardy perennial plant in the genus of Angelica It has been traditionally used as a tonic to restore vitality [1]. In the early 2000s, investigations were expanded to the metabolic effects of Angelica keiskei and/or its bioactives (chalcone and coumarins) including lipid metabolism [3], insulin resistance [4], arterial relaxation [5], oxidative stress [6], inflammation [7], and chemical-induced hepatotoxicity [8,9]. The bulk of ingested sugar is rapidly metabolized into glucose6phosphate which is trapped inside cells. This pathway enables rapid conversion of excess glucose to lipid, resulting in elevated blood lipid levels and exacerbation of triglyceride (TG) storage in the liver. Excess hepatic TG accumulation sensitizes the liver to induce oxidative stress, insulin resistance, and inflammation, eventually leading to hepatocellular damage and death [10]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
