Abstract
Chemotherapy‐induced peripheral neuropathy (CIPN) with restriction of daily activity (RDA) was common consequence of oxaliplatin‐based chemotherapy in colorectal cancer patients. CIPN with RDA and negative mood may impact the quality of life (QoL). However, the relationships among RDA, mood, and QoL remain unclear. This was a cross‐sectional relative study in which four instruments were used: the Neuropathic Pain Symptom Inventory was used to measure the severity of CIPN; the Screening of Activity Limitation and Safety Awareness scale was used to evaluate RDA; the Profile of Mood States Short Form was used to assess negative mood; and the Functional Assessment Cancer Center Therapy‐Colorectal scale version 4 was used to evaluate QoL. Relationships among the variables were analyzed by bivariate correlation, hierarchical multiple linear regression, and Baron and Kenny's mediation testing. One hundred three colorectal adenocarcinoma patients with CIPN after receiving oxaliplatin‐based chemotherapy were enrolled. Patients had mild‐to‐moderate CIPN and mild RDA. Significant correlations were found between CIPN and mood (r = 0.425, P < 0.001), between RDA and mood (r = 0.343, P < 0.001), and between RDA and QoL (r = 0.285, P < 0.01). RDA and mood may impact QoL. Under mediation effect analysis, mood mediated 38.48% of the effect of RDA on QoL (P < 0.001). Negative mood is the major factor impacting QoL in colorectal cancer patients with CIPN. Although the management of CIPN and RDA can prevent irreversible functional problems, enhancing the adaption of mood disturbance can strongly promote their QoL.
Highlights
| 964 experience acute or chronic peripheral neuropathy.[3,4] These acute peripheral neuropathic symptoms may develop after the first course of treatment but may be relived spontaneously between courses.[4,5] When the total accumulative dose of oxaliplatin is approximately 540‐850 mg/m2, the symptoms may last for months or years.[3,5,6]
The aim of this study was to investigate the relationships among restriction of daily activity (RDA), mood, and quality of life (QoL) in colorectal cancer patients with chemotherapy‐induced peripheral neuropathy (CIPN)
The present study revealed significant correlations of RDA with mood and QoL, compared with mild‐to‐moderate correlations of CIPN with mood and QoL
Summary
| 964 experience acute or chronic peripheral neuropathy.[3,4] These acute peripheral neuropathic symptoms may develop after the first course of treatment but may be relived spontaneously between courses.[4,5] When the total accumulative dose of oxaliplatin is approximately 540‐850 mg/m2, the symptoms may last for months or years.[3,5,6]. When CIPN occurs in the upper limbs, patients may have interference with dressing, household chores, hobbies, and work.[9] As they wear clothing, they may have problems with buttoning, using zippers, fastening brassieres, tying neckties, and putting on earrings or jewelry.[5,10] They may have difficulty in opening jars, removing cold objects from the refrigerator, threading a needle, using remote controls or controllers for video games or picking up small objects from the ground.[10,11] When CIPN develops in the feet, the patient's walking, climbing stairs, hiking, running, biking, exercise, or standing for a long time may be interfered.[10] The evoked hypersensitivity as touching cold objects causes patients to not go barefoot, and the paresthesia, dysesthesia, neuropathic pain, painful muscle spasm, and leg weakness lead to imbalance.[9,10,11] the risk of falls increases in colorectal cancer patients with CIPN.[12]. The aim of this study was to investigate the relationships among RDA, mood, and QoL in colorectal cancer patients with CIPN
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