Abstract
The paper studies the impact of selenium organic preparation DAFS-25k on thyroid capacity in pregnant cows. A stud farm which the work is done in is a biogeochemical province distinguished by a sharp deficit of selenium and iodine in the diet. DAFS-25k had been implanted into the animals subcutaneously during 1 month 30 days before the predicted calving. A sterile 0.6 % DAFS-25k oil solution was used in doses containing 2 mg/cow/day, 6 mg/cow/day and 12 mg/cow/day. It was found that the cows’ diet is deficient in iodine and selenium by 63 and 82 % respectively. Daily use of selenium in DAFS-25k in the dose range causes a decrease in the concentration of free thyroxine due to deiodination activating by selenium dependent deiodinases of the first and second types. Consequently, there is a progressive increase in the blood content of total triiodothyronine in all experimental animals as relating to the background values. In this case, the concentration of thyroid-stimulating hormone decreases in blood serum by the 30th day according to the principle of negative feedback. In control animals, an increase in the serum concentration of thyroid-stimulating hormone reached the point 1.8 by the 30th day, total triiodothyronine increased by 14 and 19 % by the 21st day and the 30th day respectively, while the concentration of free thyroxine was reduced by 19 % by the 30th day. The use of selenium in the setting of iodine deficiency leads to aggravation of iodine deficiency.
Highlights
Selenium refers to a group of seven elements
The triiodothyronine total concentration progressively increased by 27 % (p
The endemicity for selenium and iodine deficiency [2] of the region, in which the experiment was carried out, has been confirmed by an analysis of the animals diet as well as development of the diseases caused by chronic selenium deficiency in livestock of different sex and age groups, such as white muscle disease, endemic goiter, according to the reports of the veterinary specialists of Agricultural production cooperative-collective farm “Luch”
Summary
Selenium refers to a group of seven elements (iron, calcium, magnesium, iodine, selenium, zinc, copper). The iodine content in the main components of the agricultural landscapes of Udmurtia is low This fact is confirmed by endemic pathologies in humans and animals, which is associated with impaired thyroid function. Researchers from different countries have confirmed that lack of selenium and iodine in the diet of farm animals leads to impaired reproductive function with a change in the ovarian cycle, infertility, emergence and development of acute and chronic endometritis, late arrival in sexual heat and birth of non-viable young animals, which certainly is an objective basis for the study of pathological conditions caused by the lack of these trace elements in order to study the pathogenesis of animals’ endocrinous status and finding effective therapeutic drugs [7, 11]. In this regard, studying the role of drugs containing trace elements on the structure and function of thyroid is of great interest [12, 13]
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