Abstract

We read with interest the article by Achilles et al. [1] in a recent issue of the Journal of Thrombosis and Haemostasis, in which the authors raised a concern regarding the safety of the oral direct thrombin inhibitor (ODTI) dabigatran. The authors aimed to investigate a potential mechanism involved in the increased risk of myocardial infarction (MI) observed in several trials of patients treated with dabigatran when compared head-to-head with patients treated with indirectly acting therapeutic anticoagulants. In this brief report, platelet reactivity and thrombin receptor expression were measured in 13 patients before and after planned initiation of dabigatran medication. This article is protected by copyright. All rights reserved.

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