DABCO mediated one pot synthesis of 2‐(3‐benzyl‐2, 6‐dioxo‐3, 6‐dihydropyrimidin‐1[2H]‐yl)‐N‐(4‐(1, 3‐dioxo‐1H‐benzo [de]isoquinolin‐2[3H]‐yl) aryl) acetamides as antimicrobial agents

Abstract

AbstractWe report herein DABCO mediated one pot synthesis of 2‐(3‐benzyl‐2, 6‐dioxo‐3,6‐dihydropyrimidin‐1[2H]‐yl)‐N‐(4‐(1,3‐dioxo‐1H‐benzo[de]isoquinolin‐2[3H]‐yl) aryl) acetamides (4a‐j). The silent features of this new one pot synthesis include the shorter reaction time, high yields, simple workup, and simultaneous formation of N‐Amide and N‐benzyl bonds in the one pot. The newly synthesized compounds (4a‐j) were characterized by different spectral techniques such as IR, 1H‐NMR, 13C‐NMR, HRMS. All the synthesized compounds were evaluated for their anti‐bacterial and anti‐fungal activities. The anti‐bacterial activities results reveal that the compounds 4a, 4g, 4i, and 4j are most active against S. aureus. In the case of B. subtilis the compounds 4a, 4i, and 4j are found to be most active. The compounds 4c, 4e, 4i, and 4j are most active against E. coli. In the case of P. aeruginosa 4a, 4i & 4j are found to be more active. On the other hand, the anti‐fungal activity result shows that the compounds 4d, 4f, 4i, and 4j are more active against A. niger. The compounds 4a, 4d, 4i, and 4j are found to be more active against C. albicans.