Da li kod starih treba primenjivati terapiju statinima?

Abstract

The vast majority of studies on the use of statins in the elderly population, relate to rosuvastatin, atorvastatin. In general, the elderly do not use the highest doses of statins, but moderate doses for the secondary and lower doses for the primary prevention of cardiovascular diseases. One of the reasons for this practice is receiving a larger number of drugs for already existing chronic diseases (polypharmacy, comorbidities) and fear of drug interactions. In the secondary prevention of cardiovascular diseases, the use of statins is mandatory, while in the primary prevention of cardiovascular diseases in the elderly population, lower doses of statins are recommended, primarily rosuvastatin and atorvastitin, as more effective drugs, with longer half-lives and fewer side effects. The principle of statin use in the elderly population would refer to the decision to start therapy and the type of statin, adapted to each patient individually, as well as the beginning with smaller doses that would gradually increase.