Da li je uz pomoć odgovarajućih indeksa moguća predikcija bubrežnog popuštanja kod pacijenata sa histopatološkom potvrdom gastrointestinalne metaplazije?

Demet Sengul

doi:10.24125/sanamed.v14i1.322

Abstract

Objectives: Gastric intestinal metaplasia has traditionally been associated with gastric adenocarcinoma. Gastric intestinal metaplasia is usually related to the Helicobacter pylori infection, older ages, smoking history, and consumption of strong spicy foods, socioeconomic status presence of IL10-592 C/A. The purpose of the present research study was to evaluate the simple laboratory parameters in subjects with gastric intestinal metaplasia. Findings: From May 2018 and October 2018, a total of 541, 281 male and 260 female, consecutive cases with gastric intestinal metaplasia with the mean age of 58.5 ± 15 years had been enrolled retrospectively with the exclusion of the cases with severe underlying disease, including the gastric cancer and gastric resection. The gastroscopy with the antral biopsy had been performed for all the cases and the biopsy samples had been evaluated for the presence of gastric intestinal metaplasia by Hematoxylin and Eosin and Helicobacter pylori status by Giemsa. The chi-squared test and independent t test were used for the comparison. The mean serum urea level detected as 34.2. ± 16.1 mg/dL in the gastric intestinal metaplasia and 31.2 ± 13.1 mg/dL in the control (95% CI from 32,3 to 34,6; p = 0.013), while the mean serum creatinin level 0.84 ± 0.28 mg/dL in the gastric intestinal metaplasia and 0.80 ± 0.26 mg/dL in the control (95% CI from 0,80 to 0,85; p = 0.042). The gastric intestinal metaplasia was detected mostly in elderly and male, regarding the multiple logistic regression (p < 0.001). Conclusion: The serum urea and creatinin levels may serve as a simple clinical tool to predict the cases patients at risk for gastric intestinal metaplasia.

Highlights

Gastric intestinal metaplasia (GIM), characterised by either the enteric or colonic mucosal immigration into the gastric mucosa, is prevalent in subjects, living in Asia and could lead to the gastric carcinoma at a rate of approximately 1%, annually (1)
The gastroscopy with the antral biopsy had been performed for all the cases and the biopsy samples had been evaluated for the presence of gastric intestinal metaplasia by Hematoxylin and Eosin and Helicobacter pylori status by Giemsa
The serum urea and creatinin levels may serve as a simple clinical tool to predict the cases patients at risk for gastric intestinal metaplasia

Summary

Introduction

Gastric intestinal metaplasia (GIM), characterised by either the enteric or colonic mucosal immigration into the gastric mucosa, is prevalent in subjects, living in Asia and could lead to the gastric carcinoma at a rate of approximately 1%, annually (1). Both atrophic gastritis and GIM have been implicated in the gastric carcinogenesis and should be tracked by endoscopic screening programmes (2). The risk factors have been reported as the presence of Helicobacter pylori infection, older ages, smoking history, strong spicy food consupmtion, occupation status and presence of IL10-592 C/A (3). The role of facilitative laboratory tools to detect GIM remains largely unknown

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